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Psychiatric Manifestations in a Postmenopausal Woman Caused by Prolonged Testosterone Pellet Therapy
Naveena Daram1, Morgan Wilhoite1, Emily Hurley1
1Department of Obstetrics and Gynecology, Wright State University, Dayton, and the Department of Reproductive Endocrinology and Infertility and the Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio.
Background:
Supplemental testosterone therapy is widely used in postmenopausal patients to treat issues such as low libido, fatigue, bone density concerns, and muscle strength. However, long-term effects of testosterone use are not well understood.
Case:
A 58-year-old postmenopausal woman was admitted after experiencing severe psychiatric symptoms, including anxiety, paranoid delusions, agitation, and impulsive thoughts. After extensive psychiatric treatment, it was determined that her symptoms were linked to long-term testosterone pellet therapy prescribed by a holistic practitioner.
Conclusion:
Prolonged testosterone therapy may precipitate psychiatric symptoms in postmenopausal patients, emphasizing the need for greater vigilance in the prescribing and monitoring of hormone therapies.
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