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Related Concept Videos

Ion Channels01:19

Ion Channels

91.1K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
91.1K

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Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
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Light-Sensitive Ion Channel Delivery System for Ion-Interference Tumor Therapy.

Yueyue Lu1, Yuxin Wu1, Canhong Zhu1

  • 1Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory ofOrganosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.

JACS Au
|September 26, 2025
PubMed
Summary

This study introduces a novel light-sensitive nanocapsule system that delivers artificial proton channels to cancer cells. This system disrupts tumor cell ion balance, leading to apoptosis and offering a new cancer treatment strategy.

Keywords:
artificial proton channelcell apoptosision channel delivery systemnanocapsulequinoline helix

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Biology

Background:

  • Artificial ion channels show promise for cancer therapy by disrupting cellular ion balance.
  • Targeting cancer cell membranes with artificial ion channels is a developing therapeutic strategy.

Purpose of the Study:

  • To develop a de novo-designed ion channel delivery system (ICDS) for cancer treatment.
  • To investigate the potential of light-sensitive nanocapsules to induce apoptosis in tumor cells via ion homeostasis disruption.

Main Methods:

  • Self-assembly of nanocapsules using host-guest complexation of azobenzene-modified quinoline helix (artificial proton channel) and α-cyclodextrin.
  • Endocytosis of nanocapsules into tumor cells, followed by ultraviolet (UV) light-induced release of proton channels.
  • Assessment of ion channel effects on subcellular membranes, including organelle neutralization, mitochondrial membrane potential, and reactive oxygen species (ROS) levels.

Main Results:

  • Nanocapsules successfully delivered artificial proton channels into tumor cells.
  • UV light triggered the release of proton channels, which disrupted intracellular ion homeostasis.
  • Disruption led to organelle dysfunction, elevated ROS, and ultimately induced cancer cell apoptosis.

Conclusions:

  • The developed ion channel delivery system (ICDS) effectively induces cancer cell apoptosis through ion interference.
  • This represents a novel antitumor strategy utilizing artificial ion channels and light-sensitive nanocarriers.
  • The findings suggest new therapeutic avenues for artificial ion channels in oncology.