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Emerging Research on Gene Delivery to the Nucleus via DNA Origami
Sierra Sterling1, Yin Wei2, Gaurav Arya3
1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30322, United States.
JACS Au
|September 26, 2025
Summary
DNA nanostructures, particularly DNA origami, are emerging as advanced nanocarriers for cellular delivery. Recent research focuses on using these DNA nanostructures for efficient gene delivery, expanding therapeutic applications.
Area of Science:
- Biotechnology
- Nanotechnology
- Molecular Engineering
Background:
- Structural DNA nanotechnology utilizes DNA to create designer nanostructures.
- These nanostructures have applications in materials science, biological research, and therapeutics.
- DNA nanostructures offer programmability, biocompatibility, and functionality for nanocarrier development.
Purpose of the Study:
- To review the emerging research on DNA nanostructures as nanocarriers for cellular delivery.
- To highlight the expansion of DNA origami applications into gene delivery.
- To provide perspectives on challenges and opportunities in this field.
Main Methods:
- Review of recent scientific literature on DNA nanostructures and cellular delivery.
- Analysis of DNA origami's role in folding and delivering gene sequences.
- Synthesis of current research trends and future outlook.
Main Results:
- DNA nanostructures, especially DNA origami, are increasingly used as nanocarriers.
- Emerging efforts demonstrate the capacity of DNA origami for gene delivery.
- This field has expanded from small molecules and short nucleic acids to gene delivery.
Conclusions:
- DNA nanostructures represent a promising platform for advanced cellular delivery systems.
- DNA origami's ability to compact gene sequences facilitates gene delivery applications.
- Further research is needed to address challenges and capitalize on opportunities in DNA-based nanocarriers.
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