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[Acute renal failure due to vitamin D toxicity].

Cora Mjeldheim Wærp1, Jostein Wågen Hauge2, Fridtjof Heyerdahl3

  • 1Medisinsk klinikk, Sykehuset i Vestfold, Tønsberg.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|September 26, 2025
PubMed
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Severe vitamin D intoxication can occur from concentrated supplements bought online. This case highlights the dangers of excessive intake, leading to hypercalcemia and acute kidney injury.

Area of Science:

  • Endocrinology
  • Nephrology
  • Nutritional Science

Background:

  • Vitamin D intoxication is a rare but serious condition.
  • Over-the-counter vitamin D supplements, especially highly concentrated ones purchased online, pose a risk.
  • Excessive vitamin D intake can lead to severe health complications.

Purpose of the Study:

  • To present a case of severe vitamin D intoxication.
  • To highlight the potential dangers of consuming highly concentrated vitamin D supplements bought online.
  • To discuss the clinical presentation, management, and outcomes of vitamin D intoxication.

Main Methods:

  • Case report of a previously healthy man.
  • Clinical assessment including laboratory tests (creatinine, calcium, vitamin D levels).

Related Experiment Videos

  • Renal biopsy to evaluate kidney damage.
  • Treatment with intravenous fluids.

    • Main Results:

    • The patient presented with nausea, fatigue, frequent urination, hypercalcemia, and acute renal failure.
    • Vitamin D levels were significantly elevated.
    • Kidney biopsy revealed nephrocalcinosis.
    • Renal function normalized within a year after treatment, though vitamin D levels remained high for six months.

    Conclusions:

    • Careless use of highly concentrated over-the-counter vitamin D supplements can be dangerous.
    • Vitamin D intoxication can lead to severe hypercalcemia and acute kidney injury.
    • Prompt treatment and monitoring are crucial for managing vitamin D intoxication.