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[Acute renal failure due to vitamin D toxicity]
Cora Mjeldheim Wærp1, Jostein Wågen Hauge2, Fridtjof Heyerdahl3
1Medisinsk klinikk, Sykehuset i Vestfold, Tønsberg.
Summary
Severe vitamin D intoxication can occur from concentrated supplements bought online. This case highlights the dangers of excessive intake, leading to hypercalcemia and acute kidney injury.
Area of Science:
- Endocrinology
- Nephrology
- Nutritional Science
Background:
- Vitamin D intoxication is a rare but serious condition.
- Over-the-counter vitamin D supplements, especially highly concentrated ones purchased online, pose a risk.
- Excessive vitamin D intake can lead to severe health complications.
Purpose of the Study:
- To present a case of severe vitamin D intoxication.
- To highlight the potential dangers of consuming highly concentrated vitamin D supplements bought online.
- To discuss the clinical presentation, management, and outcomes of vitamin D intoxication.
Main Methods:
- Case report of a previously healthy man.
- Clinical assessment including laboratory tests (creatinine, calcium, vitamin D levels).
- Renal biopsy to evaluate kidney damage.
- Treatment with intravenous fluids.
Main Results:
- The patient presented with nausea, fatigue, frequent urination, hypercalcemia, and acute renal failure.
- Vitamin D levels were significantly elevated.
- Kidney biopsy revealed nephrocalcinosis.
- Renal function normalized within a year after treatment, though vitamin D levels remained high for six months.
Conclusions:
- Careless use of highly concentrated over-the-counter vitamin D supplements can be dangerous.
- Vitamin D intoxication can lead to severe hypercalcemia and acute kidney injury.
- Prompt treatment and monitoring are crucial for managing vitamin D intoxication.
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