[Pathological diagnosis, work-up and reporting of breast cancer. Recommendations of the 5th Hungarian Consensus...

Following a wide interdisciplinary consultation, the present recommendations have been finalized after their public discussion at the 5th Hungarian Consensus Conference on Breast Cancer. The recommendations cover non-operative, intraoperative and postoperative diagnostics, the determination of prognostic and predictive markers and the content of the cytology and histology reports. Furthermore, it touches some special issues such as the current status of multigene molecular markers, the role of pathologists in clinical trials and prerequisites for their involvement. The most important changes include the integration of the ASCO/CAP HER2 assessment guidelines from 2023, the reformulation of the role of cytology in breast cancer diagnostics, diagnostic categories of non-operative lymph node assessment, and the revision of PD-L1 assessment related information. The recommendations include the core and non-core elements of the ICCR (International Collaboration on Cancer Reporting) breast cancer related datasets.