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Updated: Jan 16, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
Published on: June 27, 2020
Advantages and Possibility of Transcription Factors FOXOs in HCC
Gu Xiufeng1, Hu Zhiping2, Wang Jingzhi3
1Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Wuhan, Hubei, China.
Abstract:
The forkhead frame O protein (forkhead box class O proteins, FOXOs) is a highly conserved family of transcription factors, consisting of four members: FOXO 1, FOXO 3, FOXO 4, and FOXO 6. The FOXOs protein family is a ubiquitously expressed transcription factor involved in the regulation of cell cycle, cell proliferation, apoptosis, autophagy, DNA repair, antioxidative stress, and many other biological activities and plays a very important role in both physiological and pathological aspects. It is noteworthy that recent studies show that FOXOs have a significant role in the occurrence and development of tumors, particularly in primary hepatocellular carcinoma (hepatocellular carcinoma, HCC), it possesses numerous advantages. In this paper, we will summarize the structural and functional characteristics of FOXOs and summarize their tumor role and advantages in HCC, to provide new ideas for HCC research and promote the generation of more favorable prevention and treatment strategies.
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