A Rare Genital Concomitant Presentation of Extracavitary Primary Effusion Lymphoma and Squamous Cell Carcinoma

Primary Effusion Lymphoma (PEL) is a rare subtype of large B-cell lymphoma characterized by malignant effusions in body cavities, typically without solid masses. Commonly affected areas include pleural, pericardial, and peritoneal spaces. However, PEL can present as Extracavitary Primary Effusion Lymphoma (EC-PEL) with solid tumor masses in different organs. We encountered a unique case of EC-PEL in an HIV-infected patient presenting concomitant with a squamous cell carcinoma as a penile mass. This case highlights the diverse presentations of PEL and the importance of considering lymphomatous involvement in uncommon sites, particularly in immunocompromised individuals. To our knowledge, this is the first EC-PEL case presenting as a penile mass, in association with an invasive squamous cell carcinoma.