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Reducing State Anxiety Using Working Memory Maintenance
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Linking subjective experience of anxiety to brain function using natural language processing.

Peter A Kirk1, Purnima Qamar1, Jacob Lentz1

  • 1Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD, 20892, USA.

Social Cognitive and Affective Neuroscience
|September 26, 2025
PubMed
Summary
This summary is machine-generated.

Anxiety symptoms may alter brain activity in the insula during movie watching, influencing how individuals recall details. This research explores subjective anxiety experiences in clinical neuroscience.

Keywords:
anxietydevelopmentlanguagemovie fMRInatural language processingnaturalistic

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Area of Science:

  • Neuroscience
  • Clinical Psychology
  • Cognitive Science

Background:

  • Anxiety research often focuses on behaviors and neurophysiology, particularly amygdala, insula, and cingulate cortex activity.
  • It remains unclear if these neural circuits underpin the subjective experience of anxiety, a key challenge for clinical neuroscience.

Purpose of the Study:

  • To investigate the relationship between brain activity, subjective anxiety experience, and recall.
  • To explore how anxiety symptoms influence neural responses to an anxiogenic stimulus.

Main Methods:

  • Used functional magnetic resonance imaging (fMRI) to scan pediatric participants (with and without anxiety disorders) while viewing an animated movie.
  • Quantified semantic content and valence of participants' verbal responses about the movie using natural language processing algorithms.

Main Results:

  • Widespread brain activity, including in the anterior insula cortex, correlated with participants' narrative descriptions of the movie.
  • Anxiety symptoms were associated with insula responses, narrative recall, and appraisals of the movie.

Conclusions:

  • Anxiety symptoms may shape insula activity patterns during movie viewing.
  • This influences the specific details participants later recall, offering insights into subjective emotional experiences in anxiety.