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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Related Experiment Video

Updated: Jan 16, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
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Platelet Transfusion Practices in the ICU: A Prospective Multicenter Cohort Study.

Stefan F van Wonderen1, Senta Jorinde Raasveld1,2, Andrew W J Flint3,4

  • 1Department of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.

Critical Care Medicine
|September 26, 2025
PubMed
Summary
This summary is machine-generated.

Platelet transfusions are given to a small percentage of ICU patients, primarily for bleeding or prophylaxis. Practices and adherence to transfusion thresholds vary significantly across different global economic regions.

Keywords:
intensive care unitplateletthresholdsthrombocytopeniatransfusion

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Area of Science:

  • Critical Care Medicine
  • Hematology
  • Transfusion Medicine

Background:

  • International data on platelet transfusion practices in intensive care units (ICUs) is limited.
  • Understanding current transfusion rates, indications, and adherence is crucial for optimizing patient care.

Purpose of the Study:

  • To assess the occurrence rate of platelet transfusions in ICUs globally.
  • To provide an overview of current platelet transfusion practices, including indications, thresholds, and adherence.
  • To analyze variations in these practices across different geo-economic regions.

Main Methods:

  • International prospective cohort study involving 233 centers in 30 countries.
  • Inclusion of adult patients admitted to the ICU during a designated study week.
  • Data collection on platelet transfusion events, indications, pre-transfusion counts, and adherence to thresholds.

Main Results:

  • 6% of 3643 ICU patients received platelet transfusions, mainly for active bleeding (42%) or prophylaxis (33%).
  • Median pre-transfusion platelet count was 44 × 10^9/L, varying by indication.
  • Transfusion thresholds were documented in 51% of cases, with 16% non-adherence; practices differed significantly by geo-economic region.

Conclusions:

  • Platelet transfusions are administered to a minority of critically ill patients, primarily for bleeding or prophylaxis.
  • Significant variations in platelet transfusion occurrence, indications, and threshold adherence exist across geo-economic regions.