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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

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Phenylethyl Alcohol-Based Polymeric Nanogels Obtained Through Polymerization-Induced Self-Assembly Toward Achieving

Rui Xie¹, Xinru Gao¹, Ketao Liu¹

¹Biomass Molecular Engineering Center, Department of Materials Science and Engineering, Anhui Agricultural University, Hefei 230036, China.

Gels (Basel, Switzerland)

|September 26, 2025

Summary

Researchers developed novel phenylethyl alcohol nanogels using polymerization-induced self-assembly. These nanogels show potent antibacterial activity against E. coli, offering a new strategy against antibiotic resistance.

Keywords:

abiotic resistance antibacterial polymer nanogels polymerization-induced self-assembly

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Area of Science:

Polymer Chemistry
Materials Science
Microbiology

Background:

Bacterial resistance necessitates novel antibiotic alternatives.
Phenylethyl alcohol shows antimicrobial potential but faces limitations in water dispersion and stability.
Existing antibiotic systems face challenges in drug delivery and efficacy.

Purpose of the Study:

To develop stable, water-dispersible phenylethyl alcohol-based nanogels.
To investigate the antimicrobial efficacy of these nanogels against bacteria.
To establish a platform for designing nanostructures for antimicrobial applications.

Main Methods:

Utilizing polymerization-induced self-assembly with in situ reversible addition-fragmentation chain-transfer (RAFT) polymerization.
Synthesizing well-defined copolymers (PTEGx-co-PPMAy) with controlled molecular weights and narrow polydispersity.
Characterizing nanogel morphology and evaluating antibacterial activity using minimum inhibitory concentration (MIC) and Scanning Electron Microscopy (SEM).

Main Results:

Successfully synthesized phenylethyl alcohol-based nanogels with diverse morphologies.
Demonstrated potent antibacterial activity, with PTEG30-co-PPMA70 achieving an MIC of 62 μg mL-1 against E. coli.
Identified membrane disruption as the bactericidal mechanism, with enhanced efficacy against Gram-negative bacteria.

Conclusions:

Established a robust platform for creating phenylethyl alcohol nanogels with tunable structures.
The developed nanogels offer a promising strategy to combat bacterial resistance.
Addressed limitations of phenylethyl alcohol and conventional antibiotic systems through advanced nanogel design.