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Dissociation Between Tumor Response and PTTM Progression During Entrectinib Therapy in NTRK Fusion-Positive Colon

Hideki Nagano1, Shigekazu Ohyama1, Atsushi Sato1

  • 1Department of Surgery, Marunouchi Hospital, Matsumoto 390-8601, Nagano, Japan.

Current Oncology (Toronto, Ont.)
|September 26, 2025
PubMed
Summary

A rare case of pulmonary tumor thrombotic microangiopathy (PTTM) occurred in colon cancer treated with entrectinib. Despite tumor response, PTTM progressed, leading to fatal respiratory failure, highlighting the need for vascular-targeted therapies.

Keywords:
acute respiratory failureentrectinibneurotrophic tropomyosin receptor kinase gene fusionpulmonary hypertensionpulmonary tumor thrombotic microangiopathyright heart failuretransverse colon cancer

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