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In-Hospital Mortality Among Patients Undergoing Percutaneous Pericardiocentesis for Pericardial Effusion with and
Ju Young Bae1, Dae Yong Park2, Soumya Banna3
1Division of Cardiovascular Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY 10065, USA.
Current Oncology (Toronto, Ont.)
|September 26, 2025
Summary
Patients undergoing pericardiocentesis for malignant pericardial effusions (MPE) face higher in-hospital mortality compared to those with non-malignant effusions (NMPE). This study highlights significant differences in outcomes, including increased mortality risk for MPE patients.
Area of Science:
- Cardiology
- Oncology
- Inpatient Medicine
Background:
- Malignant pericardial effusions (MPE) are prevalent, yet outcomes post-pericardiocentesis compared to non-malignant pericardial effusions (NMPE) are not well-defined.
- Understanding these differences is crucial for patient management and resource allocation in cardiovascular and oncological care.
Purpose of the Study:
- To compare clinical outcomes, focusing on in-hospital mortality, between patients undergoing pericardiocentesis for MPE versus NMPE.
- To identify secondary outcomes including discharge disposition, length of stay, and hospitalization costs.
Main Methods:
- Retrospective analysis of the US National Inpatient Sample (NIS) database from January 2016 to December 2020.
- Identification of hospitalizations involving pericardiocentesis, stratifying patients into MPE and NMPE cohorts.
- Primary outcome: in-hospital mortality; Secondary outcomes: discharge disposition, length of stay, hospitalization costs.
Main Results:
- A total of 85,125 patients were analyzed, with 24,740 in the MPE group and 60,385 in the NMPE group.
- In-hospital mortality was significantly higher in the MPE group (11.8%) compared to the NMPE group (8.2%) (OR 1.50, p < 0.001).
- MPE patients had a higher risk of non-home discharge, longer length of stay, and greater total hospitalization costs.
Conclusions:
- Patients with MPE undergoing pericardiocentesis exhibit significantly higher in-hospital mortality than those with NMPE.
- Malignant pericardial effusions are associated with increased resource utilization, including longer hospital stays and higher costs.
- Further research is needed to optimize treatment strategies for MPE, especially in patients with limited life expectancy.
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