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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

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Sjogren's Disease and Elevated Cardiovascular Risk: Mechanisms and Treatment

Jennifer Behbodikhah1, Billy Ding1, Belin Jacob1

  • 1Department of Medicine, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA.

Journal of Cardiovascular Development and Disease
|September 26, 2025
PubMed

Insights

Sjogren's Disease (SjD) may accelerate cardiovascular disease (CVD) risk, despite often being underrecognized. This review explores SjD's impact on heart health, potential mechanisms, and monitoring tools.

Area of Science:

  • Cardiology
  • Rheumatology
  • Immunology

Background:

  • Autoimmune disorders accelerate atherosclerosis and cardiovascular disease (CVD).
  • Systemic lupus erythematosus and rheumatoid arthritis are linked to increased CVD.
  • Sjogren's Disease (SjD) has an indolent course, with its chronic inflammatory burden and CVD risk often underrecognized.

Purpose of the Study:

  • To review the association between Sjogren's Disease and cardiovascular disease.
  • To explore potential risk factors and mechanisms linking SjD to accelerated CVD.
  • To discuss the impact of CVD and SjD treatments on heart health and monitoring subclinical atherosclerosis in SjD patients.

Main Methods:

  • Literature review of studies investigating cardiovascular disease in Sjogren's Disease.
  • Analysis of potential mechanisms contributing to CVD in SjD.
  • Evaluation of current treatment impacts and monitoring tools for subclinical atherosclerosis.

Main Results:

  • Conflicting results exist regarding the direct link between SjD and CVD.
  • SjD's chronic inflammation may contribute to accelerated atherosclerosis.
  • Standard treatments for both CVD and SjD may influence cardiovascular outcomes.

Conclusions:

  • The relationship between Sjogren's Disease and cardiovascular disease requires further elucidation.
  • Identifying and managing CVD risk factors in SjD patients is crucial.
  • Clinically relevant tools for monitoring subclinical atherosclerosis are important for SjD patient care.

Keywords:
Sjögren’s diseaseatherosclerosisautoimmune disordercardiovascular riskdyslipidemiatreatment

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