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Angiotensin-Converting Enzyme Gene Polymorphisms and Diabetic Neuropathy: Insights from a Scoping Review and
Rafaela Cirillo de Melo1, Paula Rothbarth Silva2, Nathalia Marçallo Peixoto Souza2
1Undergraduation in Pharmacy, Federal University of Paraná (UFPR), Curitiba 80210-170, PR, Brazil.
Diseases (Basel, Switzerland)
|September 26, 2025
Summary
Genetic variations in the Angiotensin-converting enzyme (ACE) gene, specifically the I/D polymorphism, may influence susceptibility to diabetic neuropathy (DN). However, findings vary by ethnicity and study design, requiring further research.
Area of Science:
- Genetics
- Neurology
- Endocrinology
Background:
- Diabetic neuropathy (DN) is a common complication of diabetes mellitus (DM), affecting multiple nerve types.
- Genetic factors, including Angiotensin-converting enzyme (ACE) gene polymorphisms, are investigated for their role in DN susceptibility.
Purpose of the Study:
- To synthesize evidence on ACE gene polymorphisms and their association with DN.
- To conduct a scoping review and scientometric analysis of relevant research.
Main Methods:
- Comprehensive literature search of PubMed, Scopus, and Web of Science.
- Inclusion of observational studies on DN and ACE genotyping.
- Scientometric mapping using Bibliometrix in RStudio.
Main Results:
- 11 studies met inclusion criteria, focusing on peripheral and cardiac autonomic neuropathy.
- The ACE I/D polymorphism, particularly the D allele and DD genotype, was linked to increased DN susceptibility in over half the studies.
- The II genotype showed a protective effect in some studies, with variations noted across ethnicities and study designs.
Conclusions:
- ACE I/D polymorphism may modulate DN susceptibility, but interethnic variability and methodological differences limit definitive conclusions.
- Further standardized studies are necessary to confirm ACE gene polymorphism as a predictive biomarker for DN.
Keywords:
angiotensin-converting enzyme genebiomarkersdiabetic complicationshyperglycemiasingle-nucleotide polymorphismMore Related Videos
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