Exploring the Interplay of Antioxidants, Inflammation, and Oxidative Stress: Mechanisms, Therapeutic Potential, and...

Area of Science:

• Biochemistry
• Molecular Biology
• Clinical Medicine

Background:

• Oxidative stress, an imbalance in reactive oxygen species (ROS) and antioxidant defenses, is implicated in chronic diseases like cancer and neurodegeneration.
• Existing reviews often compartmentalize oxidative stress and inflammation, hindering clinical translation.
• Understanding the interplay between redox balance and inflammatory pathways is crucial for therapeutic development.

Purpose of the Study:

• To provide an integrated analysis of oxidative stress and inflammation, linking molecular mechanisms to clinical findings.
• To explore the dual roles of natural and synthetic antioxidants in redox regulation and inflammatory signaling.
• To highlight recent clinical evidence, therapeutic challenges, and innovative strategies for chronic disease management.

Main Methods:

• Comprehensive literature review integrating biochemical, preclinical, and clinical data.
• Analysis of molecular mechanisms connecting oxidative stress, inflammation, and disease pathogenesis.
• Evaluation of current and emerging antioxidant-based therapeutic strategies.

Main Results:

• Oxidative stress and inflammation are deeply interconnected, influencing multiple chronic disease pathways.
• Antioxidants exhibit dual roles, modulating redox balance and inflammatory responses.
• Recent clinical findings reveal both potential and challenges in antioxidant-based therapies.

Conclusions:

• An integrated understanding of oxidative stress and inflammation is vital for effective chronic disease treatment.
• Antioxidant-based therapies hold promise but require further refinement and innovative approaches.
• Future research should focus on translating redox biology insights into clinically applicable treatments.