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Related Experiment Video

Updated: Jun 19, 2026

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

Polydatin Modulates Inflammatory Cytokine Expression in Lipoteichoic Acid-Stimulated Human Dental-Pulp Stem Cells.

Rawan Al-Ateeq¹, Mona Elsafadi², Manikandan Muthurangan²

¹Department of Restorative Dental Sciences, College of Dentistry, King Saud University, Riyadh 12372, Saudi Arabia.

Journal of Functional Biomaterials

|September 26, 2025

Summary

Polydatin treatment reduced inflammatory cytokines like IL-6 and TNF-α in dental pulp stem cells stimulated by lipoteichoic acid (LTA). This natural compound also increased IL-10 levels, suggesting a role in managing dental caries inflammation.

Keywords:

anti-inflammatory dental pulp inflammation lipoteichoic acid polydatin stem cells

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Area of Science:

Oral Biology
Immunology
Pharmacology

Background:

Dental caries initiation involves Gram-positive bacteria and lipoteichoic acid (LTA) binding to dental pulp cells.
This interaction triggers immune responses, inflammation, and potential pulp necrosis.
Polyphenolic compounds, such as polydatin, show promise in modulating inflammatory mediators for healing.

Purpose of the Study:

To evaluate the effect of polydatin on cytokine expression in lipoteichoic acid (LTA)-stimulated human dental-pulp stem cells (hDPSCs).
To assess the impact of varying polydatin concentrations on key inflammatory markers.

Main Methods:

Human dental-pulp stem cells (hDPSCs) were stimulated with LTA and subsequently treated with polydatin (0.01 µM, 0.1 µM, 1 µM).
Cytokine levels (IL-6, IL-8, IL-10, TNF-α) were quantified using RT-qPCR and ELISA.

Main Results:

Polydatin significantly decreased Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-α) levels.
Reduced Interleukin-8 (IL-8) mRNA and protein levels were observed with specific polydatin concentrations.
Interleukin-10 (IL-10) levels were significantly increased across all tested polydatin concentrations.

Conclusions:

Polydatin effectively modulates inflammatory cytokine production in LTA-stimulated hDPSCs.
The compound suppresses pro-inflammatory cytokines (IL-6, IL-8, TNF-α) and enhances the anti-inflammatory cytokine IL-10.
Polydatin demonstrates potential therapeutic benefits for managing inflammation associated with dental caries.