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Systematic review of c-met as a prognostic indicator in esophageal cancer patients: a meta-analysis study
Zipu Yu1, Guofei Zhang1, Gang Shen2
1Department of Thoracic Surgery2nd Affiliated Hospital, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang, China.
Objectives:
To evaluate c-met expression as a reliable prognostic indicator for survival in esophageal cancer patients.
Methods:
Eligible articles from relevant studies or databases were retrieved via systematical search. The association between c-met expression and survival results was evaluated by pooled effect in esophageal cancer patients. A fixed-effects or random-effects model was used to calculate the pooled risk ratios (RRs) and corresponding 95% confidence intervals (CIs).
Results:
13 studies were up to the selection criteria. Our meta-analysis indicated that c-met positive expression correlated with lower overall survival (RR = 0.40; 95%CI: 0.25-0.63), disease-free-survival (RR = 0.30; 95%CI: 0.21-0.44), disease specific survival (RR = 0.53; 95%CI: 0.35-0.80) in esophageal cancer patients.
Conclusion:
C-met positive expression indicates a poor prognosis in esophageal cancer patients. Further studies are required to confirm our result.
