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Authors' Response to Weng et al.'s Comment on "Association of GLP1-Receptor Agonists with Risk of Hepatocellular

Ishak A Mansi1,2, Moheb Boktor3

  • 1Education Services, Orlando VA Healthcare System, 13800 Veterans Way, Orlando, FL, 32827, USA. Ishak.mansi@va.gov.

Drug Safety
|September 26, 2025
PubMed
Abstract

No abstract available in PubMed .

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Grignard reagents are one of the most commonly used reagents used to synthesize alcohols from carbonyl compounds. Grignard reagents are organomagnesium halides with a highly polar carbon–magnesium bond. Due to the partial ionic nature of the C–Mg bond, the carbon functions as a strong nucleophile and attacks electrophiles like carbonyl carbon.
Magnesium from the reagent coordinates with carbonyl oxygen, further reducing the carbonyl carbon's electron density. Thus, the carbonyl carbon is a...