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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

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Published on: December 18, 2012

Scedosporium-induced keratitis: insights from a case study.

Liya Fathima¹, L Annapurneswari¹, Pooja Rao²

¹Department of Microbiology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India.

Journal of Ophthalmic Inflammation and Infection

|September 26, 2025

Summary

This summary is machine-generated.

A rare fungal eye infection caused by Pseudallescheria boydii (Scedosporium apiospermum) occurred after a traumatic eye injury. This case highlights the challenges in diagnosing and treating this emerging opportunistic infection.

Keywords:

Pseudallescheria Boydii Scedosporium apiospermum Eye injury Keratitis

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Area of Science:

Ophthalmology
Mycology
Infectious Diseases

Background:

Pseudallescheria boydii (Scedosporium apiospermum) is an emerging opportunistic fungal pathogen.
While typically causing invasive infections in immunocompromised individuals, it can rarely affect the eye.

Purpose of the Study:

To report a challenging case of Pseudallescheria boydii keratitis.
To discuss the diagnostic and management difficulties associated with this rare fungal infection following traumatic ocular injury.

Main Methods:

A case report of a 38-year-old female with a history of penetrating eye injury.
Clinical examination revealed a limbal ulcer with a thinned cornea and mucoid discharge.
Corneal scrapings confirmed the presence of P boydii; treatment included broad-spectrum antibiotics and antifungals.

Main Results:

The patient presented with pain, itching, watering, and blurred vision following trauma.
Initial treatment with antibiotics and antifungals (moxifloxacin, tobramycin, natamycin, fluconazole) provided no symptomatic improvement.
The patient was referred for keratoplasty due to the lack of response to medical management.

Conclusions:

Pseudallescheria boydii, a soil saprophyte, can enter the body through penetrating injuries.
This fungus is often misdiagnosed as Aspergillosis and exhibits resistance to amphotericin B and flucytosine, but susceptibility to triazoles.
Surgical intervention and combination therapy may offer better outcomes for invasive infections.