Related Experiment Video
Updated: Jan 16, 2026
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
Autosomal dominant polycystic kidney disease is not a risk factor for scoliosis
Zofia Jankowska1, Mariusz Niemczyk2
1Department of Transplantology, Immunology, Nephrology, and Internal Diseases, Medical University of Warsaw, Nowogrodzka 59, 02-006, Warsaw, Poland.
Purpose:
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic disease of the kidney. Due to the disturbances in extracellular matrix formation that are observed in ADPKD, connective tissue disorders belong to the clinical picture of the disease. Connective tissue is considered to play a role in the development of scoliosis. Consequently, ADPKD was proposed to be a risk factor for the development of scoliosis. The study was performed to test the hypothesis that ADPKD may be associated with scoliosis occurrence.
Methods:
It was a retrospective case-control study. Participants have been randomly chosen from among adult renal transplant recipients treated at our center, and divided into ADPKD (study group) and non-ADPKD (control group). Participants' chest X-ray results were assessed for scoliosis.
Results:
112 and 89 patients were included in the study group and the control group, respectively. The prevalence of scoliosis was 25.89% in the study group, and 29.21% in the control group (p = 0.60).
Conclusion:
According to our results, ADPKD is not a risk factor for the development of scoliosis.
More Related Videos
08:46Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
Published on: September 1, 2015
08:08Cell-based Assay Protocol for the Prognostic Prediction of Idiopathic Scoliosis Using Cellular Dielectric Spectroscopy
Published on: October 16, 2013
Related Concept Videos
01:35Pedigree Analysis
01:43Sex-linked Disorders
01:25Chronic Kidney Disease I: Introduction
01:21External Anatomy of the Kidney
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:11Genetic Lingo