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Dynamic Post-translational Modifications of Nuclear Lamins in Cellular Function and Pathophysiology.

Anjali Sharma1, Nabanita Das1, Rohini Bhatt1

  • 1Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India.

Sub-Cellular Biochemistry
|September 26, 2025
PubMed
Summary
This summary is machine-generated.

Nuclear lamins are vital proteins for nuclear structure. Their post-translational modifications (PTMs) regulate gene expression and cellular functions, and their dysregulation is linked to diseases like laminopathies and cancer.

Keywords:
AgeingCancerCell cycleChromatin organizationLaminopathiesNuclear laminsPTMsStress

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Nuclear lamins form the nuclear lamina, crucial for nuclear structure.
  • Emerging roles in 3D genome organization and gene regulation are recognized.
  • Post-translational modifications (PTMs) dynamically regulate lamin functions.

Purpose of the Study:

  • To explore the multifaceted roles of nuclear lamins.
  • To elucidate the impact of PTMs on lamin function and cellular processes.
  • To discuss the pathological implications of aberrant lamin PTMs in disease.

Main Methods:

  • Review of existing literature on nuclear lamins and PTMs.
  • Analysis of the functional consequences of lamin PTMs.
  • Correlation of lamin dysfunction with various pathological conditions.

Main Results:

  • PTMs like phosphorylation, acetylation, and SUMOylation critically influence chromatin stability and nuclear organization.
  • Lamin PTMs are integral to cellular responses, differentiation, metabolism, and aging.
  • Dysregulated PTM patterns are implicated in laminopathies, metabolic disorders, premature aging, and cancer.

Conclusions:

  • Aberrant lamin PTMs disrupt nuclear stability and chromatin organization, driving disease progression.
  • Targeting lamin PTMs offers potential therapeutic strategies for lamin-related disorders.
  • Restoring nuclear integrity through PTM modulation is key for improved disease outcomes.