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Related Concept Videos

Endocytosis01:16

Endocytosis

12.1K
Eukaryotic cells acquire nutrients for growth and proliferation. Nutrients and other molecules that require degradation are internalized from the extracellular space by a process called endocytosis. The term ‘endocytosis' was first coined by Christian de Duve in 1963.
Endocytosis always begins with the plasma membrane enclosing an incoming molecule to form a transport vesicle which, in some cases, can be coated with a protein called ‘clathrin.' Endocytosed material is either...
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Transcellular Transport of Solutes01:23

Transcellular Transport of Solutes

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Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
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Recycling Endosomes and Transcytosis00:58

Recycling Endosomes and Transcytosis

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The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
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Capillary Exchange01:28

Capillary Exchange

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The cardiovascular system's chief role is to disseminate gases, nutrients, waste, and other substances to the body's cells. Small molecules like gases, lipids, and lipid-soluble substances directly diffuse through capillary wall endothelial cell membranes. Glucose, amino acids, and ions, including sodium, potassium, calcium, and chloride, use transporters for facilitated diffusion via membrane-specific channels. Glucose, ions, and bigger molecules may also pass through intercellular...
10.4K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

8.7K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
8.7K
Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis01:18

Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

2.8K
Vesicular transport is a cellular process that encompasses the engulfment of particles or dissolved substances by cells. It involves endocytosis, transcytosis, and exocytosis.
Endocytosis is a cellular mechanism that involves the inward folding of the cell membrane to create vesicles that capture and transport large drug molecules. This process comprises two distinct methods: pinocytosis (often referred to as "cell drinking") and phagocytosis (often referred to as "cell...
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Enteropathy produced in mice by intergenerational transmission of small intestinal microbiota from undernourished children.

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Modulating efferocytosis in the intestinal epithelial cells during colorectal cancer.

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Related Experiment Video

Updated: Jan 6, 2026

Quantification of Efferocytosis by Single-cell Fluorescence Microscopy
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Quantification of Efferocytosis by Single-cell Fluorescence Microscopy

Published on: August 18, 2018

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Efferocytosis in Homeostasis.

Christian Maueröder1,2, Caitlin M Gillis1,2, Kodi S Ravichandran3,4,5

  • 1VIB-UGent Center for Inflammation Research, Ghent University, Ghent, Belgium.

Advances in Experimental Medicine and Biology
|September 26, 2025
PubMed
Summary
This summary is machine-generated.

Efferocytosis, the clearance of apoptotic cells, is vital for tissue repair and reducing inflammation. Disruptions in this process can lead to autoimmune diseases and fibrosis.

Keywords:
ApoptosisAsthmaDead cell clearance in the testesEfferocytosisFibrosisHomeostasisImmune toleranceLung inflammationMammary involutionSLETissue repair

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Area of Science:

  • Cell biology
  • Immunology
  • Pathology

Background:

  • Apoptotic cells are cleared efficiently by phagocytes through efferocytosis.
  • This process is crucial for maintaining tissue homeostasis and preventing inflammation.
  • Despite high daily cell turnover, dead cells rarely accumulate in healthy tissues.

Purpose of the Study:

  • To review the role of efferocytosis in restoring homeostasis after inflammation and injury.
  • To highlight the consequences of impaired efferocytosis.

Main Methods:

  • This review synthesizes current literature on efferocytosis.
  • Focuses on its mechanisms and implications in health and disease.

Main Results:

  • Efferocytosis promotes anti-inflammatory mediator secretion and tissue repair.
  • Impaired efferocytosis contributes to the development of autoimmune disorders.
  • Dysfunctional efferocytosis is implicated in fibrotic conditions.

Conclusions:

  • Efferocytosis is essential for resolving inflammation and injury.
  • Defects in efferocytosis can drive pathologies like autoimmunity and fibrosis.