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Visualization of Macrophage Lytic Cell Death During Mycobacterial Infection in Zebrafish Embryos via Intravital Microscopy
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Cell Death and Infection: Implications for Host and Microbe.

Anna Davey1, Thibaut Sanchez1, Christopher D Lucas2

  • 1Centre for Inflammation Research, Institute for Regeneration & Repair, University of Edinburgh, Edinburgh, UK.

Advances in Experimental Medicine and Biology
|September 26, 2025
PubMed
Summary
This summary is machine-generated.

Programmed cell death is crucial for tissue health. This review explores how cell death and clearance impact microbes, particularly in the gut and lungs, opening new research avenues.

Keywords:
ApoptosisBacteriaHost-microbe interactionsMetabolism

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Area of Science:

  • Immunology
  • Microbiology
  • Cell Biology

Background:

  • Programmed cell death is a highly conserved, regulated process vital for tissue homeostasis.
  • External-facing tissues like the gut and lungs interact closely with microbial communities.
  • While host responses to microbes inducing cell death are studied, microbial responses to host cell death are less understood.

Purpose of the Study:

  • To review host cell-cell communication events downstream of programmed cell death.
  • To highlight how cell death and clearance impact commensal and pathogenic microbes.
  • To focus on the interplay between host cell death and bacterial communities in the intestine and lung.

Main Methods:

  • Literature review focusing on programmed cell death, host-microbe interactions, and cell-cell communication.
  • Analysis of existing research on apoptosis, corpse clearance, and microbial metabolism.
  • Synthesis of findings related to intestinal and pulmonary environments.

Main Results:

  • Pathogenic microbes can manipulate host cell death pathways during infection.
  • Microbial metabolites released during apoptosis can be utilized by certain bacteria.
  • Host cell death processes influence the composition and behavior of microbial communities.

Conclusions:

  • Understanding the bidirectional communication between host cell death and microbes is crucial for host-microbe homeostasis.
  • Further research is needed to elucidate the specific mechanisms of interaction in tissues like the gut and lung.
  • This knowledge can inform therapeutic strategies targeting host-microbe dysbiosis.