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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

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Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

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The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Related Experiment Video

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High-throughput, Microscale Protocol for the Analysis of Processing Parameters and Nutritional Qualities in Maize Zea mays L.
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Functional factors for precision nutrition interventions in starch-based delivery systems.

Mengyuan Qin1,2, Lingjin Li1,2,3, Jing Du4

  • 1School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, PR China.

Critical Reviews in Food Science and Nutrition
|September 26, 2025
PubMed
Summary

Starch-based delivery systems offer enhanced bioavailability for functional factors in precision nutrition. These customizable systems show promise for managing chronic diseases like diabetes and cancer.

Keywords:
Starchdelivery systemfunctional foodsprecision nutrition

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Area of Science:

  • Biomaterials Science
  • Nutritional Science
  • Drug Delivery Systems

Background:

  • Chronic diseases (diabetes, cardiovascular, cancer) present global health challenges.
  • Precision nutrition aims to manage these conditions by delivering tailored functional factors.
  • Starch-based delivery systems offer biocompatibility, biodegradability, and tunable properties for enhanced efficacy.

Purpose of the Study:

  • To comprehensively analyze starch-based delivery systems for precision nutrition.
  • To examine biological barriers to oral delivery and how starch carriers overcome them.
  • To highlight applications and potential in managing chronic diseases.

Main Methods:

  • Review of literature on starch-based carriers (nanoparticles, microcapsules, hydrogels).
  • Analysis of engineering strategies to overcome oral delivery barriers.
  • Examination of targeted delivery applications for functional factors.

Main Results:

  • Starch-based systems improve stability, bioavailability, and targeted delivery of functional factors.
  • Engineered carriers effectively address biological barriers for oral administration.
  • Demonstrated potential in managing inflammatory bowel disease, diabetes, and cancer.

Conclusions:

  • Starch-based delivery systems are crucial for advancing precision nutrition.
  • These systems offer customizable solutions for personalized nutrition and chronic disease management.
  • Significant potential exists for future trends and applications in this field.