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Related Experiment Video

Updated: Jan 16, 2026

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

Pain and lymphoedema: a challenging combination.

Susan Witt^1,2, Jesús Baltasar González-Rubino^1,3, Gabriele Erbacher¹

¹Foeldi Clinic, Hinterzarten, Germany.

British Journal of Community Nursing

|September 26, 2025

Summary

This case study shows that intensive conservative treatment can effectively manage severe lymphoedema (swelling) caused by complex regional pain syndrome (CRPS), avoiding the need for amputation.

Keywords:

compression wrap lymphoedema medical adaptive compression devices pain rehabilitation wound management

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Area of Science:

Medicine
Rehabilitation Medicine
Pain Management

Background:

Complex regional pain syndrome (CRPS) can lead to severe secondary lymphoedema.
Stage III lymphoedema presents with significant limb swelling, pain, and mobility issues.
Amputation is sometimes considered for refractory CRPS-associated lymphoedema.

Purpose of the Study:

To present a case study of managing advanced lymphoedema secondary to CRPS.
To highlight the effectiveness of conservative, interdisciplinary treatment in severe cases.
To demonstrate the potential to avoid amputation through coordinated care.

Main Methods:

A 26-year-old female patient with stage III lymphoedema secondary to CRPS was treated.
An intensive, conservative, interdisciplinary, multimodal treatment approach was implemented.
Treatment included compression wraps and other therapeutic interventions.

Main Results:

Significant reduction in limb volume was achieved.
Pain associated with CRPS and lymphoedema was better managed.
The patient successfully avoided amputation.

Conclusions:

Severe CRPS-associated lymphoedema can be effectively managed with conservative, multimodal treatment.
Coordinated, interdisciplinary care is crucial for successful outcomes.
This approach offers a viable alternative to amputation in complex cases.