Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Assembly of Cytoskeletal Filaments

Assembly of Cytoskeletal Filaments

Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...

Spindle Assembly

Spindle Assembly

Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a microtubule array...

Mechanism of Filopodia Formation

Mechanism of Filopodia Formation

Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...

Cytoskeletal Coordination in Cell Migration

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Polymer-Agent: Large Language Model Agent for Polymer Design.

Journal of chemical information and modeling·2026

Same author

Lymphatic disruption drives lung transplant fibrosis through interleukin-1-mediated hyaluronan accumulation.

Science translational medicine·2026

Same author

Recapitulating apicobasal tissue polarity in extracellular matrix-incorporated airway organoids.

Biomaterials·2026

Same author

Large Language Model Agent for Modular Task Execution in Drug Discovery.

Journal of chemical information and modeling·2026

Same author

A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function.

Nature communications·2025

Same author

Comparative Single-Cell Transcriptomics Uncovers Shared and Distinct Molecular Signatures in Cystic Fibrosis and Primary Ciliary Dyskinesia.

bioRxiv : the preprint server for biology·2025

Same journal

Taphonomic analysis at Liang Bua reveals the behavioral and technological capabilities of <i>Homo floresiensis</i>.

Science advances·2026

Same journal

Targeting granule initiation and amyloplast structure to create giant starch granules in wheat.

Science advances·2026

Same journal

A meta-analysis of carbon losses and gains from tropical moist forest degradation and regeneration.

Science advances·2026

Same journal

Ancient DNA reveals elite dynastic rule among Iron Age Eurasian Steppe nomads.

Science advances·2026

Same journal

Targeting astrocytic Dp71 attenuates BBB disruption after traumatic brain injury through WTAP-associated m<sup>6</sup>A regulation of MMP2.

Science advances·2026

Same journal

Pancreatic α cells are required for nutrient homeostasis by regulating dynamic β cell networks in islets.

Science advances·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 13, 2026

Initial 3D Cell Cluster Control in a Hybrid Gel Cube Device for Repeatable Pattern Formations

Initial 3D Cell Cluster Control in a Hybrid Gel Cube Device for Repeatable Pattern Formations

Published on: March 21, 2019

AggreBots: Configuring CiliaBots through guided, modular tissue aggregation.

Dhruv Bhattaram¹, Kian Golestan¹, Xuanshuo Zhang¹

¹Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.

Science Advances

|September 26, 2025

Summary

This summary is machine-generated.

Engineered living tissue propellers, called AggreBots, allow precise control over motility by altering their shape and cilia distribution. This breakthrough enables planned and verified modifications to tissue movement for future applications.

More Related Videos

Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices

Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices

Published on: September 7, 2021

Volumetric Imaging and Analysis of Primary Cilia in Musculoskeletal Tissue using the ARL13B-CENTRIN-2 Mouse Model

Volumetric Imaging and Analysis of Primary Cilia in Musculoskeletal Tissue using the ARL13B-CENTRIN-2 Mouse Model

Published on: March 28, 2025

Related Experiment Videos

Last Updated: May 13, 2026

Initial 3D Cell Cluster Control in a Hybrid Gel Cube Device for Repeatable Pattern Formations

Initial 3D Cell Cluster Control in a Hybrid Gel Cube Device for Repeatable Pattern Formations

Published on: March 21, 2019

Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices

Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices

Published on: September 7, 2021

Volumetric Imaging and Analysis of Primary Cilia in Musculoskeletal Tissue using the ARL13B-CENTRIN-2 Mouse Model

Volumetric Imaging and Analysis of Primary Cilia in Musculoskeletal Tissue using the ARL13B-CENTRIN-2 Mouse Model

Published on: March 28, 2025

Area of Science:

Biomedical Engineering
Tissue Engineering
Biophysics

Background:

Ciliated biobots (CiliaBots) exhibit self-propulsion using motile cilia.
Existing CiliaBots show links between motility and morphology, but direct control is lacking.

Purpose of the Study:

To engineer aggregated CiliaBots (AggreBots) for enhanced control over structure and motility.
To explore guided modular aggregation of human airway epithelial spheroids (CiliaBot building blocks - CBBs).

Main Methods:

Assembled CBBs into rod, triangle, and diamond shapes (AggreBots).
Incorporated cilia-inactive CBBs (CCDC39-mutated) to create hybrid AggreBots.
Analyzed changes in tissue geometry, cilia density, and motility patterns.

Main Results:

AggreBots demonstrated altered motility patterns based on engineered shapes.
Hybrid AggreBots allowed precise modulation of active cilia distribution.
Tissue geometry was modified without compromising cilia density or boundary integrity.

Conclusions:

AggreBots offer a platform for controlling tissue motility through morphological manipulation.
This approach provides morphological "levers" for planning and verifying changes in tissue propulsion.
Demonstrates potential for engineered living tissue propellers.