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Updated: Jul 2, 2026
09:43
Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
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Small Bowel Neuroendocrine Neoplasms: A Single Tertiary Center Real World Experience
Rucsandra-Ilinca Diculescu1, Doina Istratescu2, Tudor Stroie3
1Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest; 2 Department of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. ridiculescu@yahoo.com.
Journal of Gastrointestinal and Liver Diseases : JGLD
|September 26, 2025
Summary
Small bowel neuroendocrine neoplasms (SB-NENs) are rare tumors. This study found SB-NENs have favorable outcomes, with surgery improving survival and lower tumor grade indicating a better prognosis.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Small bowel neuroendocrine neoplasms (SB-NENs) are rare, challenging tumors often diagnosed late.
- Characterizing their clinical presentation, diagnosis, and prognosis is crucial.
Purpose of the Study:
- To analyze the clinical characteristics, diagnostic approaches, and treatment strategies for SB-NENs.
- To evaluate the prognostic factors and survival rates in patients with SB-NENs.
Main Methods:
- Retrospective cohort study of 42 SB-NEN cases over five years.
- Data collection included clinicopathological features, treatments, and disease evolution.
- Overall survival was estimated at 1, 3, and 5 years.
Main Results:
- Computed tomography was the primary diagnostic imaging method.
- Surgery was the most common method for obtaining pathological specimens.
- Well-differentiated tumors (85.6%) showed a median survival of 94 months, with 5-year survival at 75.7%.
Conclusions:
- SB-NENs demonstrate favorable outcomes, with surgery enhancing survival, even in metastatic instances.
- Lower tumor grade is linked to a better prognosis.
- Somatostatin analogue therapy did not show a survival benefit.
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