Biocatalytic hydrogen-bonded organic frameworks: Design and biomedical applications

Area of Science:

• Materials Science
• Biocatalysis
• Nanotechnology

Background:

• Hydrogen-bonded organic frameworks (HOFs) are emerging porous crystalline materials with tunable structures.
• HOFs offer precise control over hydrogen-bonding networks, making them suitable for advanced applications.
• Integrating bioactive components with HOFs creates stable biocatalytic composites with enhanced efficiency.

Purpose of the Study:

• To systematically review recent advancements in HOFs-based biocatalysts.
• To analyze assembly strategies, catalytic mechanisms, and enhancement approaches.
• To highlight applications and address challenges in HOFs-based biocatalysis.

Main Methods:

• Systematic literature review of HOFs-based biocatalytic systems.
• Analysis of modular assembly strategies for HOFs-biocatalyst composites.
• Discussion of catalytic mechanisms and enhancement strategies.

Main Results:

• HOFs-based biocatalysts demonstrate exceptional structural stability and enhanced catalytic efficiency.
• Applications span biomedical engineering, enzymatic catalysis, and environmental science.
• Key challenges include balancing stability and activity, multifunctional integration, and biosafety.

Conclusions:

• HOFs-based biocatalysts represent a promising next-generation material for diverse applications.
• Addressing challenges requires strategic research in stability, multifunctionality, and biosafety.
• Future prospects involve translational development and advanced HOFs-biocatalyst systems.