Investigating the correlation between cytokine levels and prognostic factors in advanced gastric cancer: A systematic review and meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Interleukin-17 (IL-17) and Interleukin-6 (IL-6) significantly impact overall survival (OS) in advanced gastric cancer (AGC). Elevated IL-17 levels correlate with shorter progression-free survival (PFS) in AGC patients.
Area Of Science
- Oncology
- Immunology
- Molecular Biology
Background
- Advanced gastric cancer (AGC) presents significant challenges due to its aggressiveness and poor prognosis.
- Understanding the molecular drivers, particularly cytokines within the tumor microenvironment, is crucial for improving patient outcomes.
- This study investigates cytokine expression in AGC to enhance prognostic understanding.
Purpose Of The Study
- To analyze the expression levels of various cytokines in advanced gastric cancer (AGC) patients.
- To correlate these cytokine levels with clinical outcomes, including overall survival (OS) and progression-free survival (PFS).
- To identify potential prognostic biomarkers for AGC.
Main Methods
- A systematic literature search was conducted in PubMed and Google Scholar for studies on cytokine levels in AGC up to October 31, 2023.
- Survival outcomes (OS, PFS, metastasis, tumor stage) were analyzed using RevMan 5.4.1.
- Statistical significance was assessed for associations between cytokines and clinical endpoints.
Main Results
- Elevated Interleukin-17 (IL-17) levels were significantly associated with shorter progression-free survival (PFS) in AGC patients (P < 0.00001).
- Both IL-17 (P < 0.00001) and Interleukin-6 (IL-6) (P < 0.00001) significantly impacted overall survival (OS), with higher levels correlating with poorer outcomes.
- No significant associations were found for IL-2, IL-4, IL-10, or IFN-gamma with PFS, nor for IFN-gamma with OS. Metastasis and tumor stage did not show significant differences based on IL-10 or IL-17 levels.
Conclusions
- Higher levels of IL-17 are linked to shorter PFS in advanced gastric cancer.
- IL-17 and IL-6 are significant prognostic factors for OS in AGC patients.
- Further research is warranted to fully elucidate the prognostic role of cytokines in AGC.
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