Omics characteristics and epigenetic modifications of adipose-derived stem cells

Adipose-derived stem cells (ADSCs) possess multipotency to differentiate into various lineages, including adipocytes, osteoblasts, neurons, and smooth muscle cells, thereby demonstrating significant potential in tissue regeneration. Recent advances in omics technologies have enhanced our understanding of ADSC molecular profiles by transcriptomic, proteomic and lipidomic analysis. Additionally, epigenetic modifications, which mediate heritable changes in gene expression without altering the DNA sequence, play a pivotal role during the multiple lineage differentiation of ADSC. This review presents a summary of recent findings on ADSC omics and epigenetics, offering an updated perspective on their distinct attributes.