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Updated: Jan 16, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
DILIrank 2.0: An updated and expanded database for drug-induced liver injury risk based on FDA labeling and a
AyoOluwa O Olubamiwa1, Yanyan Qu1, Skylar Connor1
1Division of Bioinformatics and Biostatistics, National Center for Toxicological Research (NCTR), US Food and Drug Administration, Jefferson, AR 72079, USA.
Abstract:
Drug-induced liver injury (DILI) is of great concern in drug development and public health. DILIrank 1.0, a widely used public dataset that ranks FDA-approved drugs by their potential to cause DILI, has significantly enabled the development of new methods for improved DILI assessment. Here, we introduce DILIrank 2.0, an essential update of DILIrank 1.0, to capture new non-biologics drug and liver-related adverse event data generated since its inception 15 years ago. Using DILIrank 2.0, we also observe changes in the DILI profiles of approved drugs following the introduction of different FDA regulatory programs. DILIrank 2.0 is an up-to-date resource that offers opportunities for supporting DILI safety assessment, predictive model development, and evaluation of new approach methods (NAMs).
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