Single-Center Experience with AneuGuide Software-Assisted Flow Diverter Treatment for Complex Intracranial Aneurysms

To investigate the efficacy and safety of flow diverters (FDs) guided by AneuGuide software in treating complex intracranial aneurysms.

A retrospective analysis was conducted on 45 patients diagnosed with 48 complex intracranial aneurysms from August 2019 to December 2023. Among these, 21 aneurysms were treated with FDs implantation guided by AneuGuide software (ArteryFlow Technology, Hangzhou, China), and 27 aneurysms received FDs treatment without AneuGuide assistance. Immediate postoperative embolization rates, complication incidences, and clinical and imaging follow-up results were compared between the 2 groups.

A total of 49 FDs were implanted for the 48 aneurysms in the 45 patients, with 10 patients receiving additional coil embolization. No perioperative complications occurred. At 1-year follow-up, angiography showed: 9 aneurysms (18.8%) were grade B (partially visible), and 39 aneurysms (81.3%) were grade C or D (near-total occlusion), of which 37 (77.1%) were completely occluded (grade D). Multivariate cox regression analysis revealed that the AneuGuide group had a significantly higher complete occlusion rate at follow-up compared to the non-AneuGuide group (hazard ratio = 2.290, P = 0.044). One patient in the non-AneuGuide group developed in-stent stenosis without clinical symptoms. No new neurological deficits were observed in any of the patients during the follow-up period.

FD placement for complex intracranial aneurysms assisted by AneuGuide software is a safe and effective treatment. Further prospective studies are needed to validate these findings.