Lessons Learned from Sepsis Microlearning Intervention

Eduardo R Osegueda1,2,3, Ben Webber4, Tanvi Mehta5

  • 1Division of Health Policy & Management, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States.

Applied Clinical Informatics
|September 26, 2025
PubMed

Insights

An electronic health record (EHR)-embedded microlearning intervention did not improve sepsis care, failing to reduce antibiotic delay. The intervention

Area of Science:

  • Healthcare Quality Improvement
  • Medical Education Technology
  • Sepsis Management

Background:

  • Improving early sepsis recognition and treatment is critical for reducing patient mortality.
  • Despite quality improvement initiatives, adherence to sepsis best practices in an academic health system remained suboptimal.
  • Electronic health record (EHR) systems offer potential platforms for delivering targeted interventions.

Purpose of the Study:

  • To develop and evaluate an EHR-embedded microlearning intervention aimed at improving adherence to sepsis care best practices.
  • To assess the intervention's impact on reducing antibiotic delay and improving secondary sepsis care outcomes.

Main Methods:

  • A randomized stepped-wedge trial was conducted, with randomization at the nursing block level.
  • The microlearning intervention was delivered via EHR alerts.
  • Antibiotic delay and secondary outcomes were extracted from the EHR and analyzed using mixed models.

Main Results:

  • The microlearning intervention did not significantly reduce antibiotic delay (mean difference = 0.71 hours; p = 0.49).
  • The intervention, despite over 30,000 alert firings, was viewed only 30 times by nursing staff.
  • No significant improvement in sepsis care outcomes was observed.

Conclusions:

  • EHR-embedded microlearning delivered through disruptive alerts was not an effective or accessible channel for nursing staff.
  • The intervention's content may have addressed knowledge gaps, but the delivery method hindered engagement and impact.
  • Future interventions should consider more accessible delivery channels to improve sepsis care adherence.

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