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Antipsychotics for Parkinson's disease: a protocol for a systematic review with network meta-analysis and trial
Johanne Juul Petersen1,2, Caroline Barkholt Kamp3, Sophie Juul3,4,5
1Rigshospitalet Copenhagen Trial Unit, Copenhagen, Denmark johanne.juul.petersen@ctu.dk.
BMJ Open
|September 26, 2025
Summary
This systematic review protocol outlines the evaluation of antipsychotics for Parkinson's disease psychosis. It aims to assess the safety and efficacy of these drugs in managing psychotic symptoms while considering potential harms.
Area of Science:
- Neurology
- Psychiatry
- Clinical Pharmacology
Background:
- Parkinson's disease (PD) is a progressive neurological disorder with increasing global incidence.
- Parkinson's disease psychosis (PDP) is a common neuropsychiatric complication, often treated with antipsychotics.
- A comprehensive evaluation of antipsychotic use in PD patients is lacking.
Purpose of the Study:
- To systematically review the beneficial and harmful effects of antipsychotics in patients with Parkinson's disease.
- To assess the impact of antipsychotics on psychotic symptoms and overall patient well-being.
- To provide evidence-based guidance on antipsychotic use in PD.
Main Methods:
- Protocol for a systematic review of randomized clinical trials.
- Comprehensive literature search across major databases and trial registries.
- Data extraction and risk of bias assessment using Cochrane Risk of Bias tool-V.2.
- Synthesis of evidence through aggregate, trial sequential, and network meta-analysis.
- Assessment of evidence certainty using GRADE and CiNeMA approaches.
Main Results:
- This section is not applicable as this is a protocol and does not contain results.
Conclusions:
- This section is not applicable as this is a protocol and does not contain results.
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