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DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens

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Published on: February 1, 2020

Risk Factors for Early Recurrence of Resectable Pancreatic Cancer.

Ryuichiro Kimura^1,2, Yoshihiro Miyasaka^1,3, Kukiko Noma²

¹Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Anticancer Research

|September 26, 2025

Summary

Pancreatic cancer recurrence after surgery is common. T3 tumors and incomplete (R1) resections predict early recurrence and poor survival, suggesting a need for multidisciplinary therapy.

Keywords:

Risk factor early recurrence pancreatic cancer resectable

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Area of Science:

Oncology
Surgical Oncology
Gastroenterology

Background:

Pancreatic cancer (PC) has a poor prognosis and is difficult to cure.
Resectable pancreatic cancer (RPC) treatment involves surgery and chemotherapy.
Early recurrence (ER) is frequent after curative resection of RPC.

Purpose of the Study:

To identify perioperative clinicopathological factors predicting ER in RPC patients.
To stratify RPC patients based on ER risk.
To improve prognostic assessment for RPC.

Main Methods:

Retrospective analysis of 303 RPC patients undergoing pancreatectomy.
Definition of ER as recurrence within six months postoperatively.
Comparison of clinicopathological characteristics between ER and non-ER groups.

Main Results:

66 (21.8%) patients experienced ER.
T3 tumors and R1 resection were significantly associated with ER.
A risk stratification identified high-risk (T3/R1) patients with significantly worse overall survival (OS).
Large tumors (≥25 mm) were an independent risk factor for R1 resection.

Conclusions:

T3 tumors and R1 resection are independent predictors of ER and poor prognosis in RPC.
RPC patients with T3 tumors or large tumors (≥25 mm) require consideration for multidisciplinary therapy.