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Biomedical and Clinical Sciences
Oncology and Carcinogenesis
Predictive and prognostic markers
Elucidating the Genetic Contribution to Nasopharyngeal Carcinoma Risk Through Matrix Metalloproteinase-11 (MMP-11) Genotypic Analysis

Elucidating the Genetic Contribution to Nasopharyngeal Carcinoma Risk Through Matrix Metalloproteinase-11 (MMP-11) Genotypic Analysis

Shih-Wei Hsu ^1,2,3, Che-Lun Hsu ^4,5, Hou-Yu Shih ^1,6, Kai-Yuan Chen ^1,7, Yun-Chi Wang ^1,6, Chia-Wen Tsai ^1,6, Te-Chun Hsia ⁶, DA-Tian Bau ^8,6,9, Wen-Shin Chang ^10,6

Shih-Wei Hsu ^1,2,3, Che-Lun Hsu ^4,5, Hou-Yu Shih ^1,6

¹Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
²Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
³National Defense Medical Center, Taipei, Taiwan, R.O.C.
⁴Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan, R.O.C.
⁵Department of Otorhinolaryngology, Asia University Hospital, Taichung, Taiwan, R.O.C.
⁶Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
⁷Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
⁸Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; 013280@tool.caaumed.org.tw.
⁹Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.
¹⁰Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; 031002@tool.caaumed.org.tw.

⁰Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.

Anticancer Research +

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September 26, 2025

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September 26, 2025

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View abstract on PubMed

Summary

This summary is machine-generated.

Single nucleotide polymorphisms in MMP-11 do not independently affect nasopharyngeal carcinoma (NPC) risk. However, MMP-11 gene variants interact with environmental factors like alcohol and betel quid use, potentially influencing NPC development.

Area Of Science

Oncology
Genetics
Environmental Health

Background

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy with complex causes, including Epstein-Barr virus, genetics, and environment.
Matrix metalloproteinase-11 (MMP-11) is overexpressed in NPC, but its genetic contribution to NPC risk is unknown.

Purpose Of The Study

To investigate the association between four MMP-11 single nucleotide polymorphisms (SNPs) and NPC risk.
To explore potential gene-environment interactions between MMP-11 SNPs and risk factors like smoking, alcohol consumption, and betel quid chewing.

Main Methods

A case-control study involving 208 NPC patients and 416 controls from Taiwan.
Genotyping of four MMP-11 SNPs (rs738791, rs2267029, rs738792, rs28382575) using logistic regression.
Stratified analyses to assess gene-environment interactions.

Main Results

No significant independent association was found between MMP-11 genotypes and NPC risk.
Significant interactions were observed between MMP-11 variants (rs2267029, rs738792) and alcohol drinking or betel quid chewing.
A borderline interaction was noted between rs738791 and smoking.

Conclusions

MMP-11 polymorphisms alone do not appear to increase NPC susceptibility.
Gene-environment interactions between MMP-11 variants and lifestyle factors may play a role in NPC pathogenesis.
Further research in diverse populations is warranted to elucidate the role of MMP-11 in NPC.

Keywords:

Alcohol drinking betel quid chewing genotype matrix metalloproteinase-11 nasopharyngeal carcinoma polymorphism smoking

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Single Nucleotide Polymorphisms-SNPs

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

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