Related Experiment Video
Updated: Jan 16, 2026
08:34
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
20.9K
Carbon-Ion Radiotherapy for Prostate Cancer in Hemodialysis Patients
Hikaru Imafuku1,2, Kotaro Terashima3, Kaori Fukunishi1
1Ion Beam Therapy Center, SAGA-HIMAT Foundation, Saga, Japan.
Anticancer Research
|September 26, 2025
Summary
Carbon ion radiation therapy (CIRT) is safe for prostate cancer patients on hemodialysis, showing limited toxicity. This suggests CIRT is a viable treatment option for this specific patient group.
Area of Science:
- Oncology
- Radiation Oncology
- Nephrology
Background:
- Carbon ion radiation therapy (CIRT) is established for cancer treatment.
- Its safety and efficacy in prostate cancer patients undergoing hemodialysis remain under-investigated.
- Hemodialysis patients present unique challenges for cancer treatment toxicity assessment.
Purpose of the Study:
- To evaluate the toxicity and safety of CIRT for prostate cancer in patients on hemodialysis.
- To determine the clinical outcomes and side effects of CIRT in this specific population.
Main Methods:
- Retrospective analysis of 13 hemodialysis patients with prostate cancer treated with CIRT.
- CIRT delivered via passive scattering or scanning techniques (51.6 Gy (RBE) in 12 fractions).
- Toxicity assessed using Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.
Main Results:
- Acute genitourinary (GU) toxicity: Grade 1 in 3 patients, Grade 2 in 2 patients.
- Late gastrointestinal toxicity: Grade 1 in 1 patient.
- No Grade 3 or higher toxicities observed; 9 patients achieved recurrence-free survival.
Conclusions:
- CIRT is safely administered to prostate cancer patients on hemodialysis.
- Observed toxicities were within acceptable limits for this population.
- CIRT shows potential as a safe and effective treatment option for hemodialysis patients with prostate cancer.
Related Concept Videos
01:24Hemodialysis II: Procedure and Complications
648
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
648
01:25Hemodialysis III: Nursing Management
748
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
748
01:25Hemodialysis I: Introduction
1.4K
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
1.4K
01:28Chronic Kidney Disease III: Interprofessional Care
344
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
344
01:15Dialysis
1.6K
Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
1.6K
01:27Dialysis
1.2K
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
1.2K