Pancancer Landscape of Long Non-coding RNA Expression and Immune Status of the Tumor Microenvironment in Japanese Cancer Patients
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View abstract on PubMed
Summary
This summary is machine-generated.This study identified 12 long non-coding RNA (lncRNA) genes associated with a strong immune response and positive cancer prognosis. Two lncRNAs show potential as biomarkers for predicting patient outcomes and immune cell infiltration.
Area Of Science
- Genomics and Molecular Biology
- Cancer Research
- Immunology
Background
- Long non-coding RNAs (lncRNAs) play crucial roles in cellular processes.
- lncRNAs are increasingly recognized for their involvement in cancer development and progression.
- Characterizing lncRNAs in cancer patients is essential for understanding their functional significance.
Purpose Of The Study
- To identify and classify lncRNAs based on their association with immune response genes.
- To investigate the relationship between lncRNAs and cancer prognosis.
- To explore the potential of lncRNAs as biomarkers for cancer immunotherapy.
Main Methods
- Differential expression analysis of 435 lncRNAs in 5,013 cancer patients.
- Correlation analysis of 80 commonly expressed lncRNAs with immune response genes using Pearson's correlation and TIMMUSCORA.
- Receiver operating characteristic (ROC) analysis to assess lncRNA association with tumor-infiltrating lymphocyte (TIL) status.
- Multivariate Cox proportional hazards model for cancer prognostic analysis.
Main Results
- 80 lncRNAs were identified and classified into high, intermediate, and low immune status score groups.
- High-scoring lncRNAs demonstrated high sensitivity in identifying TILs, including CD8+ T cells and B cells.
- 11 lncRNAs were identified as significant prognostic genes.
Conclusions
- Twelve lncRNA genes with high immune scores were identified as immunogenic and associated with CD8+ T cell infiltration.
- Two specific lncRNAs emerged as indicators of a positive cancer prognosis.
- These 12 lncRNAs hold potential as biomarkers for predicting immune response and favorable prognosis in cancer patients.
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