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Updated: Jan 16, 2026

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
Published on: June 26, 2018
N-type Ca2+ channels mediate the stimuli-dependent α-synuclein secretion in mouse striatum
Emmanouela Leandrou1,2, Ioanna Chalatsa1, Kostas Vekrellis2
1Department of Chemistry, School of Sciences, National and Kapodistrian University of Athens; Panepistimioupolis Zografou, Athens, 15772, Greece.
None:
The secretion of α-synuclein from presynaptic terminals is controlled by neuronal activity through a calcium-dependent mechanism. To address the role of voltage gated calcium channels in this process, we used reverse brain microdialysis to monitor α-synuclein release in vivo in the presence of selective channel inhibitors. Our results revealed that the ω-conotoxin GVIA-sensitive N-type calcium channels are the major mediators of stimulated α-synuclein secretion in mouse striatum.
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