Related Experiment Video
Updated: Jan 16, 2026
08:53
Localization, Identification, and Excision of Murine Adipose Depots
Published on: December 4, 2014
42.0K
Health of adipose tissue: oestrogen matters
Victoria J Vieira-Potter1, Gargi Mishra2, Kristy L Townsend2
1Department of Nutrition and Exercise Physiology, Division of Foods, Nutrition and Exercise Sciences, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, MO, USA. vieirapotterv@missouri.edu.
Nature Reviews. Endocrinology
|September 27, 2025
Summary
Declining estrogen levels during menopause lead to increased visceral fat and cardiometabolic disease risk. Understanding estrogen
Area of Science:
- Endocrinology
- Metabolic Health
- Women's Health
Background:
- Menopause is associated with increased visceral adipose tissue accumulation and cardiometabolic disease risk.
- Declining estrogen levels significantly impact body composition and metabolic processes.
- Adipose tissue plays a crucial role in systemic metabolism and estrogen production.
Purpose of the Study:
- To review the multifaceted roles of estrogens in adipose tissue.
- To elucidate how estrogen influences adipose tissue phenotype and function.
- To understand the link between estrogen, adipose tissue health, obesity, and metabolic disease.
Main Methods:
- Literature review of studies on estrogen signaling in adipose tissue.
- Analysis of the bidirectional relationship between adipose tissue and circulating estrogens.
- Examination of the impact of estrogen loss on adipose tissue function and mass.
Main Results:
- Estrogens are critical regulators of adipose tissue function and health.
- Adipose tissue is a significant source of circulating estrogens, particularly in women with obesity.
- Loss of estrogen effects in adipose tissue contributes to menopausal weight gain and metabolic dysfunction.
Conclusions:
- Estrogen signaling is vital for maintaining adipose tissue health and metabolic balance.
- Dysregulation of estrogen in adipose tissue contributes to obesity and associated comorbidities.
- Further research into estrogen's role in adipose tissue is crucial for managing metabolic diseases.
Related Concept Videos
01:02Hypodermis
7.3K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
7.3K
01:29Cholesterol: Significance and Regulation
1.2K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
1.2K
01:24Obesity
1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
01:27Major Hormones and Their Functions
1.7K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
1.7K
01:24Overview of Lipid Metabolism
4.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
4.8K