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Cerebral Sinovenous Thrombosis: 20 Years of Experience in a Pediatric Tertiary Center

Julia Loureiro Sion1, Daniele M Celeste2, Bernadete L Liphaus3,4

  • 1Pediatric Hematology Unit, Instituto Da Criança e do Adolescente, Hospital Das Clínicas, Faculdade De Medicina, Universidade De São Paulo, Sao Paulo, Brazil.

Pediatric Blood & Cancer
|September 27, 2025
PubMed

Insights

Cerebral sinovenous thrombosis (CSVT) in children is often linked to infections and dehydration. Anticoagulation treatment, though lengthy, showed good outcomes with no fatalities or recurrences in this pediatric study.

Area of Science:

  • Pediatric Neurology
  • Hematology

Background:

  • Cerebral sinovenous thrombosis (CSVT) is an uncommon but serious condition in children.
  • Identifying risk factors and optimizing treatment are crucial for pediatric CSVT management.

Purpose of the Study:

  • To analyze risk factors, treatment strategies, and outcomes of pediatric CSVT.
  • To evaluate the effectiveness and safety of anticoagulation in pediatric CSVT cases.

Main Methods:

  • Retrospective analysis of 44 pediatric CSVT cases from a 20-year registry.
  • Identification of risk factors, including infections and thrombophilia.
  • Review of anticoagulation treatments (low molecular weight heparin, unfractionated heparin) and their duration.

Main Results:

  • Risk factors were identified in 93% of cases, with infection being most common.
  • Anticoagulation was administered to 91% of patients, with treatment durations exceeding current guidelines.
  • Complete resolution of thrombi occurred in 49% of cases, with no recurrences or fatalities related to anticoagulation.

Conclusions:

  • Infections are a primary risk factor for pediatric CSVT.
  • Extended anticoagulation may be effective and safe in pediatric CSVT, despite exceeding current recommendations.
  • Pediatric CSVT patients treated with anticoagulation demonstrate favorable outcomes with high rates of thrombus resolution.

Keywords:
anticoagulant therapycerebral sinovenous thrombosis (CSVT)childrenlow molecular weight heparin (LMWH)thrombophilia

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