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Updated: Jul 21, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Finite Element Modeling in Left Ventricular Cardiac Biomechanics: From Computational Tool to Clinical Practice
Patrick Hoang1,2, Julius Guccione3
1School of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Abstract:
Finite element (FE) modeling has emerged as a powerful computational approach in cardiovascular biomechanics, enabling detailed simulations of myocardial stress, strain, and hemodynamics, which are challenging to measure with conventional imaging techniques. This narrative review explores the progression of cardiac FE modeling from research-focused applications to its increasing integration into clinical practice. Specific attention is given to the mechanical effects of myocardial infarction, the limitations of conventional LV volume-reduction surgeries, and novel therapeutic approaches like passive myocardial reinforcement via hydrogel injections. Furthermore, the review highlights the critical role of patient-specific FE simulations in optimizing LV assist device parameters and guiding targeted device placements. Cutting-edge developments in artificial intelligence-enhanced FE modeling, including surrogate models and precomputed simulation databases, are examined for their potential to facilitate real-time, personalized therapeutic decision-making. Collectively, these advancements position FE modeling as an essential tool in precision medicine for structural heart disease.
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