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Related Experiment Video

Updated: Jan 16, 2026

Extinction Training During the Reconsolidation Window Prevents Recovery of Fear
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Acute Restraint Stress Impairs Aversive Memory Retention but Not Memory Formation.

Aline Lima Dierschnabel1, Diana Aline Nôga1,2, Luiz Eduardo Mateus Brandão1,3

  • 1Laboratory of Neurochemical Studies, Physiology and Behaviour Department, Post-Graduation Program in Psychobiology, Federal University of Rio Grande do Norte (UFRN), Natal 59078-970, Brazil.

Biology
|September 27, 2025
PubMed
Summary
This summary is machine-generated.

Acute restraint stress (ARS) after training impairs long-term memory retention in rats by disrupting Zif268 and C-fos signaling. Stress affects memory recall more than initial formation.

Keywords:
C-fosZif268aversive memory retentionhippocampusplus-maze discriminative avoidance taskstress

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Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Molecular Biology

Background:

  • Stress significantly impacts neurochemical signaling pathways, influencing cognitive functions like memory processing.
  • The precise neurobiological mechanisms by which stress affects memory, particularly long-term retention, remain incompletely understood.

Purpose of the Study:

  • To investigate the specific effects of acute restraint stress (ARS) on the long-term retention of aversive memory.
  • To elucidate the role of neuronal activity markers, C-fos and Zif268, in stress-induced memory impairment.

Main Methods:

  • Adult male rats were subjected to either handling or acute restraint stress (ARS) immediately following training in a plus-maze discriminative avoidance task (PMDAT).
  • Immunohistochemistry was employed to assess neuronal activation, specifically measuring C-fos and Zif268 expression in the dorsal CA1 region of the hippocampus.
  • Memory retention was evaluated using the PMDAT following the stress or handling protocols.

Main Results:

  • ARS administered immediately after training did not affect initial memory formation but significantly impaired long-term memory retention.
  • Training induced a transient peak of C-fos expression 1 hour post-training and a delayed Zif268 increase at 18 hours in the dorsal CA1.
  • ARS post-training abolished the delayed Zif268 increase and altered the C-fos response, indicating disruption of key molecular signaling pathways necessary for memory consolidation.
  • The study demonstrated the critical involvement of Zif268 and C-fos signaling in maintaining long-term aversive memory (LTM) in the PMDAT.

Conclusions:

  • Acute restraint stress plays a more critical role in impairing memory retention than in the initial formation of discriminative aversive memory.
  • The findings highlight that stress-induced disruption of specific molecular signaling cascades, particularly involving Zif268 and C-fos in the dorsal CA1, underlies the deficit in long-term memory retention.