Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neuronal Communication

Neuronal Communication

Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...

Neurons as Communicators of the Brain

Neurons as Communicators of the Brain

Neurons, the fundamental units of the brain and nervous system, function as the primary transmitters of information throughout the body. Their ability to communicate through electrical and chemical signals is vital for every bodily function, from regulating the heartbeat to processing complex thoughts. Each neuron has three main components: the cell body (soma), dendrites, and an axon, each specialized to facilitate swift and efficient neural communication.
Cell Body
The cell body, also known...

The Blood-brain Barrier

The Blood-brain Barrier

Organization of the Brain

Organization of the Brain

The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...

Functional Brain Systems: Limbic System

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Krüppel-like Factor 2 (KLF2) in the Regulation of Lipid Accumulation, ROS, and Mitochondrial Functions During Foam Cell Formation in RAW264.7 Cells.

Biology·2026

Same author

Mechanisms of Ellagic Acid (EA)-Mediated Osteogenic Differentiation of Human Dental Pulp-Derived Stem Cells.

ACS omega·2025

Same author

Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke.

Biology·2025

Same author

Krüppel-like factor 2 (KLF2), a potential target for neuroregeneration.

Neural regeneration research·2024

Same author

KLF2 Regulates Neural Differentiation of Dental Pulp-derived Stem Cells by Modulating Autophagy and Mitophagy.

Stem cell reviews and reports·2023

Same author

Epigallocatechin-3-gallate inhibits osteoclastic differentiation by modulating mitophagy and mitochondrial functions.

Cell death & disease·2022

Search research articles

Related Experiment Video

Updated: Jan 16, 2026

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

Unraveling the Bone-Brain Communication Network.

Surajit Hansda¹, Hiranmoy Das¹

¹Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, ARB Suite 2116, 1406 South Coulter Street, Amarillo, TX 79106, USA.

|September 27, 2025

Summary

The bone and brain communicate bidirectionally through molecular signals, influencing each other

Keywords:

aging bone brain inflammation molecular signaling

More Related Videos

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

Published on: April 9, 2019

Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model

Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model

Published on: October 20, 2023

Related Experiment Videos

Last Updated: Jan 16, 2026

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

Published on: April 9, 2019

Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model

Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model

Published on: October 20, 2023

Area of Science:

Bone and neurobiology
Endocrinology
Molecular biology

Background:

Bone and brain exhibit shared physical, molecular, and developmental traits.
Bidirectional communication (crosstalk) exists between bone and brain systems.
This crosstalk is mediated by hormones, cytokines, extracellular vesicles (EVs), and neural signals.

Purpose of the Study:

To review the molecular basis of bone-brain crosstalk.
To highlight the roles of inflammation, aging, and regulatory pathways.
To discuss future directions in biomarker discovery and therapeutic targeting.

Main Methods:

Literature review of existing studies on bone-brain communication.
Analysis of molecular signaling pathways and transcriptional regulators.
Examination of shared biomarkers and pathological links.

Main Results:

Bone-derived factors (e.g., osteocalcin) affect cognitive functions and neurogenesis.
Brain-derived factors (e.g., leptin) influence bone remodeling.
Inflammation and aging disrupt bone-brain communication, impacting cognitive and bone health.

Conclusions:

Bone-brain crosstalk is crucial for maintaining homeostasis.
Disruptions in this axis contribute to age-related disorders like cognitive decline and osteoporosis.
Understanding this communication offers opportunities for early diagnosis and dual-targeted therapies.