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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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HSP60 and SARS-CoV-2: Les Liaisons Dangereuses
Adelaide Carista1, Melania Ionelia Gratie1, Francesco Cappello1
1Department of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy.
Biology
|September 27, 2025
Summary
Heat shock protein 60 (Hsp60) is involved in COVID-19, causing inflammation and organ damage. Hsp60 may serve as a biomarker and therapeutic target for COVID-19 and related autoimmune conditions.
Area of Science:
- Immunology
- Molecular Biology
- Pathophysiology
Background:
- Heat shock protein 60 (Hsp60) is vital for cellular homeostasis and stress response.
- Emerging evidence links Hsp60 to COVID-19, impacting immune responses, inflammation, and endothelial function.
Purpose of the Study:
- To review the multifaceted roles of Hsp60 in COVID-19.
- To explore Hsp60's implications in disease progression, post-viral complications, and therapeutic strategies.
Main Methods:
- Literature review focusing on morpho-functional aspects of Hsp60 in COVID-19.
- Analysis of Hsp60's interactions with Toll-like receptors and SARS-CoV-2 proteins.
Main Results:
- Extracellular Hsp60 exacerbates inflammation and cytokine storms via Toll-like receptor interactions.
- Molecular mimicry between Hsp60 and SARS-CoV-2 proteins suggests a role in autoimmune disorders.
- Hsp60 is implicated in endothelial damage and thromboembolic events in severe COVID-19.
Conclusions:
- Hsp60 plays a significant role in COVID-19 pathogenesis, including immune modulation and organ damage.
- Hsp60 shows potential as a biomarker for disease severity and a therapeutic target.
- Structural similarities between Hsp60 and SARS-CoV-2 raise considerations for vaccine safety and anti-tumor immunity.
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