Related Experiment Video
Updated: Jan 16, 2026
14:56
Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
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Current Insights into Obesity and m6A Modification.
1Human Phenome Institute, Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Centre, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai 201203, China.
Biomedicines
|September 27, 2025
Summary
RNA
Area of Science:
- Epigenetics
- Molecular Biology
- Metabolic Diseases
Background:
- Obesity is a global health issue linked to metabolic diseases.
- The "calories-in/calories-out" model is insufficient for obesity.
- Epigenetic regulation, especially RNA modifications, is a key focus.
Purpose of the Study:
- To review the role of N6-methyladenosine (m6A) modification in obesity.
- To elucidate the molecular mechanisms of m6A in obesity.
- To evaluate m6A as a therapeutic target for obesity.
Main Methods:
- Systematic review of current literature.
- Analysis of m6A's role in adipocyte differentiation, lipid metabolism, and energy homeostasis.
- Evaluation of m6A writers, erasers, and readers in obesity.
Main Results:
- m6A modification is crucial in obesity pathogenesis and progression.
- m6A regulates key biological processes involved in metabolic dysregulation.
- m6A pathways offer potential therapeutic targets for obesity.
Conclusions:
- m6A epigenetic modifications are pivotal in obesity.
- Targeting m6A mechanisms presents novel therapeutic strategies for obesity management.
- Further research into m6A offers new perspectives for obesity treatment.
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