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Related Concept Videos

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Regulation of Metabolism01:19

Regulation of Metabolism

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Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
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Oligosaccharide Assembly01:24

Oligosaccharide Assembly

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Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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Related Experiment Video

Updated: Jan 16, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Current Insights into Obesity and m6A Modification.

Chen Meng1, Di Yang1

  • 1Human Phenome Institute, Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Centre, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai 201203, China.

Biomedicines
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Summary
This summary is machine-generated.

RNA

Keywords:
adipogenesisepigeneticsm6A modificationmetabolic diseasesmethylationobesitytherapeutic targets

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Area of Science:

  • Epigenetics
  • Molecular Biology
  • Metabolic Diseases

Background:

  • Obesity is a global health issue linked to metabolic diseases.
  • The "calories-in/calories-out" model is insufficient for obesity.
  • Epigenetic regulation, especially RNA modifications, is a key focus.

Purpose of the Study:

  • To review the role of N6-methyladenosine (m6A) modification in obesity.
  • To elucidate the molecular mechanisms of m6A in obesity.
  • To evaluate m6A as a therapeutic target for obesity.

Main Methods:

  • Systematic review of current literature.
  • Analysis of m6A's role in adipocyte differentiation, lipid metabolism, and energy homeostasis.
  • Evaluation of m6A writers, erasers, and readers in obesity.

Main Results:

  • m6A modification is crucial in obesity pathogenesis and progression.
  • m6A regulates key biological processes involved in metabolic dysregulation.
  • m6A pathways offer potential therapeutic targets for obesity.

Conclusions:

  • m6A epigenetic modifications are pivotal in obesity.
  • Targeting m6A mechanisms presents novel therapeutic strategies for obesity management.
  • Further research into m6A offers new perspectives for obesity treatment.