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Decoding TRIP13's Role in Gastric Cancer: Implications for Prognosis and Immune Response.
Tongguo Shi1, Yu Shen1, Anjing Zhao2
1Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.
Biomedicines
|September 27, 2025
Summary
High TRIP13 expression indicates poor prognosis in gastric cancer (GC). This study found TRIP13 is elevated in GC tissues, linked to survival, and influences cell cycle and immune responses, suggesting it as a therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Genomics
Background:
- Gastric cancer (GC) is a major global health concern with significant mortality.
- The prognostic role of Thyroid Receptor Interacting Protein 13 (TRIP13) in GC is not well-defined.
- TRIP13 is implicated in tumor progression in various cancers.
Purpose of the Study:
- To investigate the prognostic significance of TRIP13 expression in gastric cancer.
- To explore the functional role and immune correlation of TRIP13 in GC.
Main Methods:
- Analysis of public cancer databases (UALCAN, GEPIA, GEO, TIMER) for TRIP13 expression.
- Immunohistochemistry (IHC) staining to assess TRIP13 protein levels and correlation with clinicopathological features.
- Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.
- Immune cell infiltration analysis.
Main Results:
- TRIP13 mRNA and protein levels are significantly upregulated in GC tissues.
- Elevated TRIP13 expression correlates with reduced overall survival and increased tumor depth in GC patients.
- TRIP13 is associated with cell cycle, DNA repair, and ferroptosis-related genes.
- TRIP13 expression negatively correlates with CD4+ T cell, CD8+ T cell, and B cell infiltration.
Conclusions:
- TRIP13 serves as a potential independent prognostic biomarker for gastric cancer.
- TRIP13 represents a promising therapeutic target for gastric cancer intervention.
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