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Chitosan-Hydrazone-Modified Calcium Phosphate Scaffolds: Fabrication, Characterization, and Drug Delivery Potential.

Teodora Jakovljević1, Jelena Stanisavljević2,3, Julijana Stevanović4

  • 1Innovation Center of the Faculty of Technology and Metallurgy Ltd., University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia.

Biomedicines
|September 27, 2025
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Summary

This study developed multi-ion doped calcium hydroxyapatite scaffolds with chitosan coatings for bone regeneration and drug delivery. The novel biomaterial platform demonstrated mechanical stability and sustained release of an anticancer hydrazone compound.

Keywords:
biomedical applicationcalcium phosphatechitosanhydrazonescaffold

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Area of Science:

  • Biomaterials Science
  • Materials Chemistry
  • Biomedical Engineering

Background:

  • Advancements in biomaterials are crucial for hard tissue regeneration and controlled drug delivery.
  • Calcium hydroxyapatite (HAp) scaffolds offer promising properties for biomedical applications.
  • Chitosan coatings enhance biomaterial stability and functionality.

Purpose of the Study:

  • To develop multi-ion doped HAp scaffolds with chitosan-based coatings for localized drug delivery.
  • To incorporate a novel hydrazone compound with potential anticancer activity.
  • To evaluate the suitability of these scaffolds for bone tissue engineering and cancer therapy.

Main Methods:

  • Synthesized multi-ion doped HAp powders (Mg2+, Sr2+, F-) via hydrothermal method.
  • Fabricated scaffolds using sponge replica technique and coated with chitosan or chitosan-hydrazone blend.
  • Analyzed scaffold properties including mechanical strength, bioactivity, cytotoxicity, and drug release profiles.

Main Results:

  • Confirmed successful incorporation of Mg2+, Sr2+, and F- dopants.
  • Chitosan coatings enhanced scaffold compressive strength and reduced degradation rate.
  • Hydrazone compound showed dose-dependent antitumor cytotoxicity and sustained release for up to 15 days.

Conclusions:

  • Multi-ion doped HAp scaffolds with chitosan-hydrazone coatings show potential for bone tissue engineering.
  • The developed platform enables localized, sustained delivery of anticancer agents.
  • This combination offers a promising approach for hard tissue regeneration and targeted cancer therapy.